| Function: | Antibiotic and Antimicrobial Agents |
|---|---|
| Certification: | GMP |
| Grade Standard: | Medicine Grade |
| Type: | Analysis reagent |
| State: | Solid |
| Volatile: | Not Volatile |
| Samples: |
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| Customization: |
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1) Product Name: Miconazole powder //CAS 22832-87-7//Miconazole nitrate
2) CAS NO: 22832-87-7
3) Active ingredients:Miconazole nitrate
4) Specification: 99%
5) Testing Method:HPLC
6) Appearance:White or almost white crystal powder
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Specification |
Standard |
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Appearance |
White or almost white crystal powder |
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Identification |
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Similar to standard |
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Appearance of solution |
The solution is clear and not more intensely cloured than reference solutions Y7 |
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Solubility |
Very slightly soluble in water; soluble in methanol; slightly soluble in alcohol |
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Angle of optical rotation |
-0.10 ----+0.10 |
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Related substances |
Each impurity |
≤0.25% |
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Total imurity |
≤0.5% |
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Melting point |
178-182°C |
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Loss on drying |
≤0.5% |
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Residue on ignition |
≤0.1% |
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Assay ( on dry basis) |
98.5-102% |
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Miconazole nitrate is also called Daknin, he's forest, miconazole, miconazole, miconazole, miconazole, synthetic 1- benzene ethyl derivatives are broad-spectrum antifungal agents is a common drug for the treatment of skin tinea, no hormones, no side effects, the the main active ingredient for miconazole. Miconazole nitrate is rarely used in China now. Its antibacterial spectrum, antibacterial activity and mechanism of action are similar to clotrimazole. It can be used as an alternative to amphotericin B in the treatment of deep fungal infections. It is suitable for the treatment of systemic and disseminated infections caused by Cryptococcus neoformans and Candida albicans. Oral absorption effect is poor, after local medication mainly stay in the lesion site, absorbed into the body very little. In vivo distribution in the body and the liquid, can penetrate into the joint, and peritoneal inflammation in the vitreous body, but in the sputum, saliva in low concentration of blood cerebrospinal fluid barrier penetration is poor, not easily through the blood-brain barrier. The binding rate of plasma protein was 90%. Metabolic inactivation through liver is an inactive metabolite.
Miconazole nitrate is an antifungal drug, the drug is Daktarin we are familiar with the commonly used in the treatment of skin tinea, by inhibiting the biosynthesis of the fungal cell membrane components of ergosterol, destroy the structure of cell membrane, the cell membrane permeability increased, resulting in the leakage of intracellular components and inhibit glucose, prevent nutrient intake, eventually fungal cell death, suitable for the treatment of tinea corporis, tinea cruris, tinea manus, tinea pedis, tinea versicolor and fungal paronychia and by yeast (such as Candida) caused by Gram positive bacteria and vaginal infection and secondary infection, external ear infections, bacterial skin infections are effective.
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