FDA Pharmaceutical Raw Material Valsartan Powder CAS: 137862-53-4

• Function: Cardiovascular Agents
• Certification: GMP, FDA
• Grade Standard: Medicine Grade
• Type: Analysis reagent
• State: Solid
• Volatile: Not Volatile
• Model NO.: USP41
• appearance: White Crystalline Powder
• Shelf Life: 3 Years
• Shipment: Promptly
• Transport Package: 25kg/Drum
• Specification: USP/BP
• Trademark: SINOAH
• Origin: China
• HS Code: 3003101100
• Production Capacity: 5mt/Month

Product Description

Cardiovascular drug Valsartan EP/USP CAS137862-53-4 Fresh stock at the most competitive prices
 

Introduction

CAS NO: 137862-53-4

Chemical Name:   N-(1- valeryl)-N-[4-[2-(1H- tetrazole -5- pyridyl) phenyl] phenmethyl]-L- Valine

Chemical Classification: Pharmaceutical apis

MF:  C24H29N5O3

Assay: 98.-102%

Quality Standard: Meets EP6

Appearance:  white or almost white crystalline powder

Package: In 25kg/ fiber drum inner polythene bags

Storage:  Cool, dry, room-temperature and well-closed container

Valsartan is used clinical for receptor antagonist of angiotensin AT1, has good effect to the different degree of hypertension patients who used other antihypertensive drugs without efficacy , is a new generation of highly efficient antihypertensive drugs.

 

White or almost white crystalline powder, odorless, slightly moist. easily dissolved in methanol and ethanol , sparingly soluble in ethyl acetate, slightly soluble in dichloromethane, almost insoluble in water.

Function

Valsartan is used clinical for receptor antagonist of angiotensin AT1, has good effect to the different degree of hypertension patients who used other antihypertensive drugs without efficacy , is a new generation of highly efficient antihypertensive drugs.
 

Application 

Valsartan (Angiotan) is an angiotensin II receptor antagonist (more commonly called an "ARB", or angiotensin receptor blocker), with particularly high affinity for the type I (AT₁) angiotensin receptor. By blocking the action of angiotensin, valsartan dilates blood vessels and reduces blood pressure.^[1] In the U.S., valsartan is indicated for treatment of high blood pressure, congestive heart failure (CHF), or post-myocardial infarction (MI).^[2] In 2005, Angiotan was prescribed more than 12 million times in the United States and global sales were approximately $6.1 billion in 2010.^[3]

A study released by the Journal of Clinical Investigation in 2007 found some efficacy in the use of valsartan in the treatment and prevention of Alzheimer's disease (in a mouse model) although such use is considered to be highly experimental. 

Specification

Item	Specification	Result	Test Method
Active Ingredeints
Assay	98.5%	99.5%	HPLC
Physical Control
Identification	Positive	Conforms	TLC
Appearance	white crystalline powder	Complies	Visual
Odor	Characteristic	Complies	Organoleptic
Taste	Characteristic	Conforms	Organoleptic
Sieve Analysis	100% pass 80 mesh	Complies	80 Mesh Screen
Loss on Drying	5% Max	3.37%	5g/105C /5hrs
Solubility Solubility	in water	Conforms	Visual
Ash	3% Max	2.84%	2g/525C/5hrs
Chemical Control
Sulphate	0.5% Max	Complies	2g/525C/5hrs
Insolubles In Ethanol	10ppm Max	5.3ppm
Ethanol Resides	0.2% Max	Complies
Arsenic (As)	NMT 2ppm	Conforms	Atomic Absorption
Cadmium(Cd)	NMT 1ppm	Conforms	Atomic Absorption
Lead (Pb)	NMT 2ppm	Conforms	Atomic Absorption
Chlorate (Cl)	NMT 1ppm	Conforms	Atomic Absorption
Phosphate Organics	NMT 1ppm	Conforms	Gas Chromatography
Heavy Metals	20ppm Max	Complies	Atomic Absorption
Pesticides Residues	NMT 1ppm	Conforms	Gas Chromatography

Packing & Storage        

Packaging Detail	0.5kgs/Al-foil bag 1.0kgs/Al-foil bag 2.0kgs/Al-foil bag 5.0 kgs/Al-foil bag 25.0 kgs/drum or upon customers' request.
Storage	Store in a well-closed container away from moisture
Shelf Life	2 years if sealed and store away from direct sun light.
Delivery Detail	within 3 days after get the payment