Top Quality with GMP Factory Promestriene CAS 39219-28-8
Details
Promestriene
Synonyms:17-Beta-Estradiol 3-Propyl Ether 17-Methyl Ether;1,3,5(10)-Estratrien-3,17-Beta-Diol 3-Propyl Ether 17-Methyl Ether;3-Propoxy-17beta-Methoxy-1,3,5(10)-Estratriene;3-Propoxy-17-Methoxyoestra-1,3,5(10)-Triene;
3-Propoxy-17b-Methoxyestra-1,3,5(10)-Trien;17(b)-17-Methoxy-3-Propoxy-Estra-1,3,5(10)-Triene;17()-17-Methoxy-3-Propoxy-Estra-1,3,5(10)-Triene
CAS: 39219-28-8
MF:C22H32O2
MW:328.49
EINECS:254-361-6
Melting point :64-66ºC
Chemical Properties:White Solid
Usage:A synthetic diethyl-ether of Estradiol with no distal hormonal effects, in patients undergoing surgical correction for stress urinary incontinence (SUI).
Packing:1kg/bag
Description
Promestriene is a topical estrogen supplements studied and developed by Monaco Dudley beauty pharmaceutical companies (wholly purchased by Merck Company of the United State in 1999) and has gotten the US patent approval in 1977 with the formulation reagents mainly including the Colpotrophine which entered into mhine (promestriene soft capsules and cream) and chlorquinaldol. Promestriene (chloroquinaldol/ Promestriene vaginal tablets) have been collected by Martindale Drug Manual and have entered into market in more than 40 foreign countries for over 40 years. Currently, in many countries, Promestriene is still the first-line drugs for the treatment of vaginal infections and atrophic vaginitis. Clinical practice has shown that it is safe and effective with the patient being well tolerated .
Promestriene is a kind of special estradiol diether with its special molecular structure making it cause the biological effects in situ without the necessity of exerting the effect after being metabolized. It has a biological half-life of being smaller than 24 h. Therefore, upon vaginal administration, drug will directly take effect on the vaginal muco), estradiol (E2), estriol (E3), LH and FSH, and can effectively prevent and treat the atrophic vaginitis with strict local estrogen effect. Compared with other drugs, advantages of promestriene lie in that it is hardly absorbed through the vagina, and thus being able to avoid the systemic risk of long-term vaginal topical supplement of estrogen with fewer adverse reactions which are of lesser extent and no systemic effects. It only has mild side effect and high safety, and the vast majority of patients are willing to accept, and therefore is an excellent choice for the treatment of atrophic vaginitis, especially for those with estrogen-dependent diseases .
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