| Customization: | Available |
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| Function: | Antibiotic and Antimicrobial Agents |
| Certification: | GMP |
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Introduction
Product Name: Monensin
Other name: 2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-beta-methoxy-alpha,gamma,2,8-tetramethyl-1,6-dioxaspiro
CAS NO.: 17090-79-8
EINECS NO.: 241-154-0
MF: C36H62O11
MW: 670.88
Monensin anticoccidiostat with wide spectrum belongs to ployether antibiotic, and is one of most typical veterinary of anticoccidiostat that is first used and most marketable in the world. Gram-positive and fungus on vegetable are sensitive to it. It can inhibits coccid's growth and finally kill it, especially to eimeria tenella coccidial.
Monensin is a polyether antibiotic of the ionophore group. It exerts an anticoccidial action against Eimeria tenella, E. acervulina, E. mivati, E. brunetti, E. maxima, E. necatrix in chickens, affecting the trophozoites in the first stage of schizogony. Its action is connected with the formation of lipophilic complexes with monovalent ions (sodium and potassium), making the membranes of the coccidial cells permeable to the ions mentioned; hence the active sodium and potassium transport is disturbed. Sodium and chloride are accumulated into the cells of the parasites, drawing water into the sporosoites, causing their swelling and rupture. It hinders the maturing of the schizonts and the development of merozoites. An additional influence is the impeded transport of carbohydrate and the active sporozoite glycolysis provoked by monensin. When orally administered to ruminants (with developed forestomachs), monensin modifies ruminal metabolism, directing it predominantly to the formation of the energetically richer propionic acid (at the expense of the other volatile fatty acids - acetic acid, lactic acid), and to inhibition of protein degradation in the rumen as a result of which feed conversion efficiency is improved and the weight gain is increased. Monensin suppresses also the formation of methane genesis of the ruminants and inhibits its eructation out of the forestomachs which spares energy losses.
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Function
Monensin can rhzomorph ion can affect insect body balance, killing insect body burst and effect on the second day after infection, ball to the first generation of schizont development stage. Mo can rhzomorph still can through improve rumen propionic acid production, improve the feed efficiency and speed of weight gain. Mo can bacteria element of gram positive bacteria, especially staphylococcus aureus, streptococcus, bacillus subtilis), pig blood flow field treponema has strong effect, but with weak in animals, for antimicrobial use.
The prevention and treatment of chicken coccidiosis, lamb, calf, rabbit coccidiosis; With bacitracin zinc, flavomycin share can increase the rate of weight gain and feed utilization rate.
Specification
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Items |
Specification |
Results |
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Characters |
white crystal powder |
white crystal powder |
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Loss on drying |
Not more than 4.0% |
1.96% |
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Content of Monensin A and B activity |
The percentage of Monensin A activity is not less than 90%. |
94.9% |
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The percentage of Monensin A and B activity is not less than 95%. |
99.1% |
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Assay |
≥800 µg/mg |
902.3 µg/mg |
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Conclusion |
This batch conforms to the monograph MONENSIN of USP33. |
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